US Patent No. 11,596,584 B2 (Steven M. Hernandez); Topix Pharmaceuticals has been awarded a patent for a topical formulation that contains a skin treatment active agent comprising about 0.01-30% retinol; an activation solvent system comprising 10-90% isopentyldiol, about 5% to about 90% dimethyl isosorbide, and a non-ionic surfactant. The formulation is comprised of polysorbate 80; caffeine; ethoxydiglycol; green tea polyphenols isolated and purified from the leaves of Camellia sinensis plants; ...